Loewith Lab

Selected Papers [ Show all publications ]

2017

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.
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Nature, ; 550 (7675): 265-269

2016

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.
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Mol Biol Cell, ; 27 (2): 397-409

2015

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
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Mol Cell, ; 58 (6): 977-988
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.
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J Biol Chem, ; 290 (24): 14963-14978

2013

TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
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Mol Cell, ; 51 (6): 829-839

2012

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
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ACS Chem Biol, ; 7 (4): 715-722
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.
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Nat Cell Biol, ; 14 (5): 542-547

2011

Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.
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EMBO J, ; 30 (15): 3052-3064
Chemical biology approaches to membrane homeostasis and function.
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Chimia (Aarau), ; 65 (11): 849-852

2010

Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.
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Sci Signal, ; 3 (153): rs4

2009

The Vam6 GEF controls TORC1 by activating the EGO complex.
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Mol Cell, ; 35 (5): 563-573
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.
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Genes Dev, ; 23 (16): 1929-1943
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.
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Mol Biol Cell, ; 20 (7): 2083-2095
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
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PLoS Biol, ; 7 (2): e38

2008

2007

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
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Mol Cell, ; 26 (5): 663-674

2006

Mutual antagonism of target of rapamycin and calcineurin signaling.
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J Biol Chem, ; 281 (44): 33000-33007
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
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Cell, ; 125 (4): 733-747