Département de biologie moléculaire
En | Fr
Andreas BOLAND, PhD
Professeur-e assistant-e
University of Geneva
Department of Molecular Biology, Sc3 2034
30, quai Ernest-Ansermet
CH-1211, Geneva 4, Switzerland
Tel: +41 22 379 61 27
Fax: +41 22 379 68 68
E-mail: Andreas.Boland@unige.ch

Structural studies of cytokine-mediated signal transduction

Cells use cytokines to communicate with each other in various complex processes, ranging from cell proliferation and differentiation to apoptosis and immune responses. These small soluble proteins recognize their target cells via specific cell surface receptors. Our laboratory is interested in dissecting the underlying molecular mechanisms of signal transduction by using an integrative structural biology approach. Employing state of the art cryo-EM will allow us to determine high-resolution structures of such receptor-ligand complexes. Defining different functional states, using other structural, biochemical and biophysical methods such as protein engineering, will help us to understand and manipulate selected signaling pathways, with putative pharmaceutical implications.

Personnal web page

Personal Information

Born 09.01.1983, Cologne, Germany

https://orcid.org/0000-0003-1218-6714
https://publons.com/researcher/2717206/andreas-boland/
https://scholar.google.co.uk/citations?user=6Vvsl-cAAAAJ&hl=en&oi=sra

Scientific Interests

Cell cycle regulation | Energy metabolism | Macromolecular machines | Cryo-​electron microscopy | Structural Biology

Positions

Since 12/2018

Associate Professor at University of Geneva
Department of Molecular Biology

03/2018-​10/2018

Investigator Scientist at MRC Laboratory of Molecular Biology, Cambridge
Structural Studies Division

Education and Training

01/2014–10/2018

Postdoc with David Barford
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

01/2009–01/2014

PhD (“summa cum laude”) with Elisa Izaurralde
Department Biochemistry, Max Planck Institute for Developmental Biology Tuebingen, Germany

10/2003–12/2008

Diploma in Biology
Friedrich Schiller University of Jena, Germany

Fellowships

2016 Marie Skłodowska-Curie postdoctoral fellowship
2014 European Molecular Biology Organization (EMBO) Long-term fellowship
2014 Career development fellowship MRC-LMB
2009 Predoctoral fellowship Max Planck Society

Institutional Responsibilities at University of Geneva

since 04/2019 Co-Coordinator of the LSSS lecture series
since 04/2019 PhD Program Co-director Molecular Biosciences
since 12/2018 Co-Organizer cryoEM facility platform (cryoGEnic)

Funding

06/2019 Novartis Foundation for Medical-Biological Research; Project Grant
05/2019 Fondation Ernst et Lucie Schmidheiny; Project Grant
04/2019 Swiss National Science Foundation; Project Grant
03/2019 Start-up grant University of Geneva

Invited Scientific Talks

2020

PhD course seminar: Introduction into cryo-electron microscopy, Speaker

2019

06/2019, 3D Electron Microscopy, Gordon Research Seminar (GRS), Hong-Kong, Keynote lecture
03/2019, Seminar series, Institute of Anatomy, University of Bern, Invited speaker
02/2019, Seminar series, FMI for Biomedical Research, Basel, Invited speaker
01/2019, “SFB 969 -Kolloquium”, University of Konstanz, Invited speaker

Organization of Conferences

2020 Inaugural cryoEM symposium "Advances in Electron Microscopy – Single Particle Analysis, Electron Diffraction & Cellular Tomography" (cryoGEnic 2020), Organiser
2019 70. Mosbacher Colloquium "High-resolution imaging of cells and molecules", Session chair

Mentoring

Postdocs

Pierre Raia (since 06/2019)
Jun Yu (since 04/2019-​9/2019)

PhD students

Lina Poulain (since 11/2018)
Anna Höfler (since 11/2018)

Master theses

we are open for applications!

Summer students

Alina Astourian (2019)

Reviewing Activity

Nature Structural & Molecular Biology

Memberships in Scientific Societies

since 2020 Member of "LS2 Life Science Switzerland"
since 2012 Member of "Gesellschaft für Biochemie und Molekularbiologie e.V." (GBM)
2011-2014 RNA Society Member

Latest Paper

Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.
, ,
Mol Cell Oncol, ; 8 (4): 1975473