Decrease in plasma membrane tension triggers PtdIns(4,5)P
2 phase separation to inactivate TORC2. 2017
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity.
TORC2 Structure and Function.
TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.
TOR Complexes and the Maintenance of Cellular Homeostasis.
Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.
TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks.
Growth control: function follows form.
Amino acid signaling in high definition.
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry.
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis.
Target of rapamycin (TOR) in nutrient signaling and growth control.
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L.
A brief history of TOR.
Chemical biology approaches to membrane homeostasis and function.
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.
The Vam6 GEF controls TORC1 by activating the EGO complex.
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis.
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology.
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
Caffeine extends yeast lifespan by targeting TORC1.
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Mutual antagonism of target of rapamycin and calcineurin signaling.
Cell growth control: little eukaryotes make big contributions.
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
TOR signaling in growth and metabolism.
The TOR signalling network from yeast to man.